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KMID : 0374019940170030233
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Ewha Medical Journal
1994 Volume.17 No. 3 p.233 ~ p.238
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Hemostatic Effects of High-Dose Aprotinin in Open Heart Operations
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Abstract
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Two groups of patients were studied to evaluate the hemostatic effects of high-dose aprotinin in open heart oprations. Aprotinin group patients(n=8) received aprotinin during entire surgical procedure. The other group patients (n=10) were served
as
control. Two groups were homogenous for base variables and for cardiopulmonary bypass duration. Postoperative bleeding was lower in aprotinin group(mean, 599ml) than control group(886ml, P<0.05). the need for banked blood decreased in aprotinin
group(aprotinin group mean, 106ml; control group mena, 387ml). Perioperative hemoglobin & platelet counts were similar each other.
We concluded that the use of high-dose aprotinin was safe and effective. It decreased blood loss and reduced the need for banked blod in open heart operations.
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